Archives
-
METTL16–SENP3–LTF Axis in HCC Ferroptosis
2026-09-28
Wang et al. identify a METTL16–SENP3–LTF regulatory axis that protects hepatocellular carcinoma cells from iron-dependent lipid peroxidation and promotes tumor progression. Their combination of molecular assays, organoids, xenografts, genetically modified mice, and human samples links m6A-dependent RNA regulation to iron handling and ferroptosis resistance.
-
Calpain–BDNF/TrkB Disruption After Maternal Surgery
2026-09-28
A pregnant-rat study links maternal non-obstetric surgery—not propofol exposure alone—to later offspring cognitive deficits, increased hippocampal calpain activity, and disruption of BDNF/TrkB-associated synaptic measures. Partial improvement after postnatal calpain inhibition or TrkB activation supports a role for this signaling axis, while leaving important questions about mechanism, timing, and translation to human pregnancy unresolved.
-
Spatially Patterned Kidney Assembloids for Disease Modeling
2026-09-27
Huang and colleagues developed mouse and human kidney progenitor assembloids that organize nephron and collecting-system lineages in a spatial arrangement resembling kidney development. The models show improved cellular complexity and function, and PKD2-deficient assembloids grown in vivo reproduce key disease features and interactions among cyst epithelium, stroma, and macrophages.
-
AR Heterogeneity Shapes Prostate Cancer Therapy Response
2026-09-26
This study connects distinct androgen receptor (AR) expression states in castration-resistant prostate cancer with different tumor behaviors and responses to androgen deprivation and enzalutamide. By combining patient-tissue analysis, engineered cell models, xenografts, and molecular profiling, the authors identify BCL-2 as a candidate vulnerability that may help guide strategies for AR-positive and AR-low disease.
-
Cy3-dCTP: From Fluorescent Label to Assay Design
2026-09-25
Cy3-dCTP enables direct fluorescent labeling of DNA and cDNA, but label density and molecular accessibility shape what the signal means. This guide connects Cyanine 3-deoxycytidine triphosphate chemistry with ordered DNA frameworks to clarify practical assay choices and important limits.
-
ALDH2 Promotes Cardiomyocyte Proliferation in Heart Failure
2026-09-25
A 2025 mouse study links ALDH2 activation with a longer early-postnatal cardiomyocyte proliferative window and increased cardiomyocyte proliferation after pressure overload. In adult mice subjected to transverse aortic constriction, Alda 1 treatment was associated with delayed heart-failure progression, identifying ALDH2 as a candidate regulator of cardiac repair that warrants further mechanistic and translational testing.
-
Estradiol Limits ER Stress After Hemorrhagic Shock
2026-09-24
This rat study links hemorrhagic-shock-associated endoplasmic reticulum stress to impaired splenic CD4+ T-cell proliferation and cytokine production. Pharmacological comparisons implicate ERα and GPR30, but not ERβ, in estradiol-associated protection, while ER-stress manipulation supports a role for this cellular stress response in the observed immune changes.
-
Sulfur Supply Delays Soybean Nodule Senescence
2026-09-24
The study links sulfur transport into soybean symbiosomes with glutathione status, reactive nitrogen species control, and the timing of nodule senescence. Its genetic and nutrient-manipulation results identify symbiosome sulfur supply as a potential lever for sustaining nitrogen fixation, while also suggesting testable ways to pair the biology with nitric oxide imaging.
-
Optimizing hiPSC-Derived Functional Platelet Production
2026-09-23
Yue and colleagues report an optimized differentiation scheme that combines increased embryoid-body input, human platelet lysate, small-molecule substitutions for cytokines, and enhanced megakaryocyte maturation. The protocol produced functional platelets in 19 days, with improved reported yield and lower cost, while leaving questions about scale-up and performance across cell lines for further study.
-
Maternal Surgery, Calpain, and Offspring Cognition
2026-09-23
The reference study identifies excessive calpain activation as a mechanistic link between maternal non-obstetric surgery during pregnancy and impaired offspring cognition. Its rescue experiments connect calpain inhibition with recovery of hippocampal BDNF/TrkB signaling, synaptic structure, neuronal markers, and behavioral performance, while also clarifying the limits of anesthetic-only interpretations.
-
WP1066: JAK2/STAT3 Inhibitor Workflow
2026-09-22
WP1066 provides a cell-permeable way to interrogate JAK2/STAT3 signaling in cancer-cell proliferation, apoptosis, and pathway-validation experiments. This guide also shows how to use it as a mechanistic perturbation when studying macrophage metabolism and regenerative biomaterials, without confusing pathway evidence with therapeutic proof.
-
Tailored CAR Macrophages for Peritoneal Metastasis
2026-09-22
Gu et al. developed a macrophage-targeted mRNA lipid nanoparticle platform to program CAR macrophages directly in the peritoneal cavity and systematically compared 36 CAR architectures. The CD3ζ-TLR4 intracellular-domain design promoted antitumor immune activity, remodeled the suppressive tumor microenvironment, and enhanced responses to PD-1/L1-axis therapy.
-
Minoxidil sulphate in Vascular Biology Research
2026-09-21
Minoxidil sulphate is a practical potassium-channel probe for pairing vasodilation-pathway experiments with renal perfusion and hair follicle assays. This guide translates sepsis vascular-reactivity findings into reproducible preparation, dosing, controls, and troubleshooting decisions.
-
SCH772984 Workflow for ERK1/2 Inhibition
2026-09-21
SCH772984 is a selective ERK1/2 inhibitor for connecting MAPK signaling with tumor-cell survival, ferroptosis, and radioresistance assays. This workflow combines phospho-protein profiling, dose-response design, and model-specific controls to improve interpretation in BRAF, NRAS, KRAS, and pancreatic cancer systems.
-
Ceftolozane/Tazobactam: Antimicrobial Innovation
2026-09-20
The reference review examines how ceftolozane/tazobactam combines an advanced antipseudomonal cephalosporin with a beta-lactamase inhibitor to address resistant gram-negative infections. Its most important contributions are the integration of PBP pharmacology, resistance biology, pharmacokinetics, pharmacodynamics, clinical efficacy, and renal dosing into one translational framework.