• Harnessing SB203580: Strategic Inhibition of p38 MAPK Pat...

  2025-10-17

  This thought-leadership article explores the mechanistic basis and translational potential of the selective p38 MAP kinase inhibitor SB203580, positioning it as a strategic tool for researchers navigating the complexities of kinase signaling, resistance development, and disease modeling. By contextualizing SB203580 within recent discoveries around adaptive resistance mechanisms—such as AKT activation in MEK1/2 inhibition-resistant cells—the article provides actionable insights and a forward-looking vision for translational scientists seeking to decode and manipulate stress and survival pathways in cancer and inflammatory disease.

• Crizotinib Hydrochloride: Unlocking Tumor Microenvironmen...

  2025-10-16

  Explore how Crizotinib hydrochloride, a potent ALK and c-Met kinase inhibitor, is transforming cancer biology research by enabling advanced dissection of tumor microenvironment dynamics. This article uniquely examines the integration of kinase inhibition with patient-derived assembloid models for profound insights into oncogenic signaling.

• br Experimental section br Conflicts of

  2023-07-06

  

  Experimental section Conflicts of interest Acknowledgments This work was partly supported by INSA-Rouen, Rouen University, CNRS, Labex SynOrg (ANR-11-LABX-0029), Région Haute-Normandie. Introduction A key component of the integrated management of key pests such as codling moth (Cydia po

• During preparation of this manuscript

  2023-07-06

  

  During preparation of this manuscript, some studies investigating effects of Sunitinib on Axl activity in renal cancer have been published [44], [45], [46], [47]. However, there are several important considerations to take into account interpreting results of these studies. First, Sunitinib doses th

• From an historical perspective ligands for GPCRs adrenaline

  2023-07-05

  

  From an historical perspective, ligands for GPCRs (adrenaline, serotonin, buy serotonin or morphine, to name a few) have been identified before their receptor counterparts, at a time when the concept of receptor itself was controversial [15]. Although many cognate receptors for endogenous ligands w

• Citral or dimethyl octadien al is a mixture

  2023-07-05

  

  Citral or 3,7-dimethyl-2,6-octadien-1-al is a mixture of two stereoisomeric monoterpene aldehydes (the trans isomer geranial, citral A (40–62%)) and the cis isomer neral, citral B (25–38%) and serves one of the main constituent of essential oils of C. citratusis used in cosmetic, food, fungicides, p

• Dopaminergic neurons are vulnerable to oxidative products an

  2023-07-05

  

  Dopaminergic neurons are vulnerable to oxidative products and inflammatory responses; these processes may play important roles in the etiology of PD. Because glial gsk3 inhibitor are the main generators of inflammatory responses in the CNS, the possibility that PD results from glial cell dysfunctio

• Since artemisinin shows low solubility and poor

  2023-07-05

  

  Since artemisinin shows low solubility and poor oral bioavailability [8], [9], derivatizations of artemisinin were carried out and yielded different semisynthetic antimalarial drugs such as artemether and sodium artesunate. Artemether (decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano [4.3-

• Assessment of antibiotic appropriateness is receiving

  2023-07-05

  

  Assessment of antibiotic appropriateness is receiving increased attention in the face of growing concerns about the emergence of MDROs, as well as the rise in adverse outcomes associated with antibiotic use such as C. difficile infection. In this study, 15% of cultured Gram-negative organisms met th

• rho kinase inhibitor Insulin is the central hormone

  2023-07-05

  

  Insulin is the central hormone involved in the control of glucose and lipid metabolism. Other nonmetabolic effects of insulin are intensively studied as well. Activation of insulin receptor not only promotes glucose uptake, protein synthesis, and inhibits lipid metabolism, but also is crucial for re

• br Angiotensin receptor neprilysin inhibitors

  2023-07-05

  

  Angiotensin receptor-neprilysin inhibitors Sacubitril/valsartan is the first-in-class ARNI, comprising of molecular moieties of valsartan (ARB) and a neprilysin inhibitor prodrug, sacubitril (AHU377) [51]. Upon ingestion, sacubitril is rapidly metabolised into an active neprilysin inhibitor, sacu

• Gliomas and Aldehyde Dehydrogenase Aldehyde dehydrogenases A

  2023-07-05

  

  Gliomas and Aldehyde Dehydrogenase Aldehyde dehydrogenases (ALDHs) are key metabolic enzymes involved in regulation of glycolysis/gluconeogenesis pathways as well as in the detoxification of endogenous and exogenous aldehydes, regulating cell function and homeostasis. ALDHs play important roles in

• The importance of insulin in controlling lipolysis and

  2023-07-05

  

  The importance of insulin in controlling lipolysis and fat mass is further emphasized by mouse models with alterations in the insulin signaling pathway of adipocytes. For example, mice with a tamoxifen-inducible knockout of the insulin receptor in mature adipocytes reveal a substantial decrease of a

• Several tertiary prevention studies are currently underway e

  2023-07-05

  

  Several tertiary prevention studies are currently underway examining the use of dutasteride for prostate cancer treatment: (1) during expectant management of prostate cancer, (2) after radical prostatectomy in men at high risk for relapse, and (3) in men with metastatic disease. The Reduction by Dut

• br Conclusion br Acknowledgments and disclosure

  2023-06-27

  

  Conclusion Acknowledgments and disclosure We thank Ms. Crystal Wylie for her help in the preparation of the manuscript. The development of the database upon which analyses of this study were dependent was supported by PO1 DC 00161 from the National Institute on Deafness and Other Communication

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