• L Family Leguminosae widely distributed in tropical and subt

  2022-06-29

  

  L. (Family Leguminosae) widely distributed in tropical and subtropical regions of the world. As a medicinal and edible plant, it is widely used in Asia, especially in China, Korea, Japan and India. It was first recorded in Shen Nong Ben Cao Jing (神农本草经), and was described having the effect of cleari

• Young et al described the role

  2022-06-29

  

  Young et al. [40] described the role of adenine monophosphate-activated protein kinase (AMPK) in the translocation of GLUT4 in the heart. The AMPK is activated during muscle contraction [74] by converting AMP to ATP. The adenosine analog, 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), is a c

• There are human genes in the SLC A family and

  2022-06-29

  

  There are 12 human genes in the SLC5A family, and 6 of these are expressed in human heart (Table 2). Little is known about SGLT proteins in the heart. Zhou et al. [56] reported the presence of SGLT1 mRNA in the human heart. Researchers have found that levels of SGLT1 mRNA in heart are approximately

• Although GLP has greater insulin releasing effects at pharma

  2022-06-29

  

  Although GLP-1 has greater insulin-releasing effects at pharmacological concentrations [10], it is apparent that the higher circulating concentrations of GIP combined with more pronounced increase in secretion following feeding make GIP the major physiological incretin [7], [11]. The peptide exerts

• Albumin is the major carrier of free fatty acids FFAs

  2022-06-29

  

  Albumin is the major carrier of free fatty acids (FFAs) in plasma [59], and harbours seven binding sites that are common to FFAs with a range of chain-lengths (C10-C18) across its three domains (Fig. 1a) [60,61]. In vitro, saturated, mono- and poly-unsaturated FFAs, with chain lengths ranging from C

• FPR activation stimulates multiple signal transduction pathw

  2022-06-29

  

  FPR1 activation stimulates multiple signal transduction pathways responsible for various neutrophil functions, such as adhesion, chemotaxis, phagocytosis, Cy7 NHS ester (non-sulfonated) of secretory granules, and superoxide anion radical (O2) production, which contribute to the physiological inflam

• br Conflict of interest br Acknowledgments The research was

  2022-06-29

  

  Conflict of interest Acknowledgments The research was funded by the Major Programs of Pharmaceutical research project of Jiangsu Province (Q2018044). Introduction Lipids are important regulators of cell death. In mammalian cells, both apoptotic and non-apoptotic cell death pathways can be

• The membrane metalloendopeptidase MME gene is located at hum

  2022-06-29

  

  The membrane metalloendopeptidase (MME) gene is located at human chromosome 3q21-27. It encodes a 100-kD type II transmembrane glycoprotein, a widely expressed membrane metalloendopeptidase that degrades a number of substrates. The active site of the enzyme faces the extracellular space. MME is wide

• MCC950 sodium In addition the interplay of

  2022-06-28

  

  In addition the interplay of membrane curvature induced tension at the fusion pore and MCC950 sodium induced tension across the PM seems to be a worthwhile target for investigation. The roles of dynamin and myosin II and especially their spatial and temporal dynamics during activity warrant further

• Liposomes that are less than

  2022-06-28

  

  Liposomes that are less than 200nm in diameter are necessary to optimize uptake of liposomes by Evans Blue tetrasodium salt (Oesterling et al., 2014). The liposomes constructed in these experiments were found to be sufficiently small in diameter for use in in vivo and in vitro experiments. Even sma

• The molecular mechanisms underlying VSMC ETB receptor upregu

  2022-06-28

  

  The molecular mechanisms underlying VSMC ETB receptor upregulation have been studied after 24–48h organ culture in both coronary and cerebral arteries. The increased expression of contractile ETB receptor at these time points has been shown to depend on transcriptional mechanisms and PKC and the ext

• br Main Text Post translational modifications including acet

  2022-06-28

  

  Main Text Post-translational modifications including acetylation, methylation, phosphorylation, and ubiquitination, of core histones directly alter DNA-histone and histone-histone interactions and thus influence nucleosome dynamics. Tight regulation of these marks is required by cells for proper

• We notice that previous reports

  2022-06-28

  

  We notice that previous reports of arsenic exposure are not completely consistent with each other, in terms of exposure-changed histone acetylations. In an early investigation, As exposure (7.5 μM) of HepG2 nisin increased H3K9ac after 24 h, when analyzed by methods of immunofluorescence and Wester

• Histone acetylation is regulated by two groups of enzymes hi

  2022-06-28

  

  Histone acetylation is regulated by two groups of enzymes, histone acetyltransferases (HATs) and deacetylases (HDACs), with antagonizing functions (Wang et al., 2009b). Among members of HATs, p300 and CBP are homologous. Both are global transcriptional co-activators (Ogryzko et al., 1996), and play

• Our results demonstrated that most of the

  2022-06-28

  

  Our results demonstrated that most of the HUA rings incubated with 100 μM TBT do not have the capacity to contract in the presence of 5-HT or exhibit very low contractions in comparison to the control. Only 23.3% of the HUA rings were able to contract. These results seem to indicate that there may b

11290 records 114/753 page Previous Next First page 上5页 111112113114115 下5页 Last page